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ID: ALA1140456

Journal: Bioorg Med Chem Lett

Title: Synthesis and screening of 3-substituted thioxanthen-9-one-10,10-dioxides.

Authors: Lory PM, Estrella-Jimenez ME, Shashack MJ, Lokesh GL, Natarajan A, Gilbertson SR.

Abstract: This manuscript describes methods appropriate for the parallel synthesis of libraries based on the tricyclic thioxanthen-9-one-10,10-dioxide scaffold. The novel compounds were synthesized from previously reported 3-chlorothioxanthen-9-one-10,10-dioxide and commercially available 3-carboxylic acid thioxanthen-9-one-10,10-dioxide. The library members were screened for activity in a fluorescence polarization assay for inhibitors of BRCT domains of breast cancer gene 1 and in cell-based secreted alkaline phosphatase reported replicon system for activity against hepatitis C virus.

CiteXplore: 17826998

DOI: 10.1016/j.bmcl.2007.07.103