Construction of polyamine-modified uridine and adenosine derivatives--evaluation of DNA binding capacity and cytotoxicity in vitro.
Basic Information
ID: ALA1140487
Journal: Bioorg Med Chem
Title: Construction of polyamine-modified uridine and adenosine derivatives--evaluation of DNA binding capacity and cytotoxicity in vitro.
Authors: Ghatnekar J, Hägerlöf M, Oredsson S, Alm K, Elmroth SK, Persson T.
Abstract: We here report the synthesis of the two polyamine-based nucleoside derivatives 5-{[bis-(3-aminopropyl)amino]acetamido-1-propynyl}uridine and 2-{[bis-(3-aminopropyl)amino]-acetamido-1-propynyl}adenosine. The various polyamine derivatives have been used in thermal melting analysis using DNA from herring testes, and in cellular studies using four different cell lines. The compounds were all found to be non-toxic, thus holding good promise for future use as siRNA building blocks.
CiteXplore: 17869123
DOI: 10.1016/j.bmc.2007.07.030
Patent ID: ┄