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ID: ALA1140498

Journal: Bioorg Med Chem Lett

Title: Synthesis of novel anilinoquinolines as c-fms inhibitors.

Authors: Smalley TL, Chamberlain SD, Mills WY, Musso DL, Randhawa SA, Ray JA, Samano V, Frick L.

Abstract: A novel series of potent substituted anilinoquinolines were discovered as c-fms inhibitors. The potency could be manipulated upon modification of the C4 aniline and C7 aryl functionality. Pharmacokinetic analysis identified a metabolically stable analog suitable for further investigative work.

CiteXplore: 17870531

DOI: 10.1016/j.bmcl.2007.09.009