Novel scaffold for cathepsin K inhibitors.

ID: ALA1140545

Journal: Bioorg Med Chem Lett

Title: Novel scaffold for cathepsin K inhibitors.

Authors: Teno N, Miyake T, Ehara T, Irie O, Sakaki J, Ohmori O, Gunji H, Matsuura N, Masuya K, Hitomi Y, Nonomura K, Horiuchi M, Gohda K, Iwasaki A, Umemura I, Tada S, Kometani M, Iwasaki G, Cowan-Jacob SW, Missbach M, Lattmann R, Betschart C.

Abstract: Pyrrolopyrimidine, a novel scaffold, allows to adjust interactions within the S3 subsite of cathepsin K. The core intermediate 10 facilitated the P3 optimization and identified highly potent and selective cathepsin K inhibitors 11-20.

CiteXplore: 17911019

DOI: 10.1016/j.bmcl.2007.09.047

Patent ID: ┄