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ID: ALA1140573
Journal: Bioorg Med Chem Lett
Title: Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification.
Authors: Heightman TD, Scott JS, Longley M, Bordas V, Dean DK, Elliott R, Hutley G, Witherington J, Abberley L, Passingham B, Berlanga M, de Los Frailes M, Wise A, Powney B, Muir A, McKay F, Butler S, Winborn K, Gardner C, Darton J, Campbell C, Sanger G.
Abstract: High throughput screening combined with efficient datamining and parallel synthesis led to the discovery of a novel series of indolines showing potent in vitro ghrelin receptor agonist activity and acceleration of gastric emptying in rats.
CiteXplore: 17942309