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ID: ALA1140603
Journal: Bioorg Med Chem Lett
Title: Simple criterion for selection of flavonoid compounds with anti-HIV activity.
Authors: Veljkovic V, Mouscadet JF, Veljkovic N, Glisic S, Debyser Z.
Abstract: Flavonoid compounds represent an important natural source of antiretrovirals for AIDS therapy due to their significant anti-HIV-1 activity and low toxicity. Here we propose a simple theoretical criterion to discriminate active from inactive flavonoids that is suitable for rapid in silico screening of flavonoid libraries, and selection and optimization of lead compounds with anti-HIV-1 activity.
CiteXplore: 17189684