Document Report Card

ID: ALA1140638

Journal: J Nat Prod

Title: Kipukasins, nucleoside derivatives from Aspergillus versicolor.

Authors: Jiao P, Mudur SV, Gloer JB, Wicklow DT.

Abstract: Seven new aroyl uridine derivatives (kipukasins A-G; 1-7) were isolated from solid-substrate fermentation cultures of two different Hawaiian isolates of Aspergillus versicolor. The structures of compounds 1-7 were determined by analysis of NMR and MS data. The nucleoside portion of lead compound 1 was assigned as uracil-1-beta-D-ribofuranoside by spectral comparison with an authentic standard. The bioactivity of the original A. versicolor extracts was accounted for mainly by the presence of the known metabolite sterigmatocystin, but kipukasins A and B showed modest activity in assays against Gram-positive bacteria.

CiteXplore: 17608440

DOI: 10.1021/np070241l