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ID: ALA1140658
Journal: Bioorg Med Chem Lett
Title: Inhibitors of anthrax lethal factor.
Authors: Gaddis BD, Avramova LV, Chmielewski J.
Abstract: An inhibitor of anthrax lethal toxin mediated cell death (1) was identified by a medium throughput cell-based screen. This compound was determined to specifically inhibit anthrax lethal factor (LF), and subsequent SAR studies produced an even more potent inhibitor (4). Mechanistic studies identified these agents as uncompetitive inhibitors of LF with Ki values of 3.0 and 1.7 microM, respectively, with good cell potency and low cytotoxicity.
CiteXplore: 17574849