Synthesis and evaluation of novel chloropyridazine derivatives as potent human rhinovirus (HRV) capsid-binding inhibitors.

Basic Information

ID: ALA1140863

Journal: Bioorg Med Chem

Title: Synthesis and evaluation of novel chloropyridazine derivatives as potent human rhinovirus (HRV) capsid-binding inhibitors.

Authors: Fan SY, Zheng ZB, Mi CL, Zhou XB, Yan H, Gong ZH, Li S.

Abstract: Human rhinovirus (HRV) is the most important etiologic agent causing common colds. No effective anti-HRV agents are currently available. In this paper we describe the synthesis and the evaluation of novel chloropyridazine derivatives (compounds 5a-g) as potent human rhinovirus (HRV) capsid-binding inhibitors. Results showed that compound 5e and 5f exhibited effective anti-HRV activity against HRV-2 and HRV-14. In addition, compound 5e and 5f showed lower cytotoxicity than Pirodavir.

CiteXplore: 19091578

DOI: 10.1016/j.bmc.2008.11.061

Patent ID: ┄