Synthesis and antitumor activity of novel amsacrine analogs: the critical role of the acridine moiety in determining their biological activity.

Basic Information

ID: ALA1140883

Journal: Bioorg Med Chem

Title: Synthesis and antitumor activity of novel amsacrine analogs: the critical role of the acridine moiety in determining their biological activity.

Authors: Chilin A, Marzaro G, Marzano C, Dalla Via L, Ferlin MG, Pastorini G, Guiotto A.

Abstract: A new series of N-[4-(2'-oxo-2H-pyrano[2,3-b]quinolin-5'-ylamino)-phenyl]-methanesulfonamides was prepared and analyzed as novel amsacrine-like derivatives. Our preliminary biological evaluation has shown that the replacement of the acridine moiety with the analogous 2-oxo-2H-pyrano[2,3-b]quinoline system drastically reduced both their anticancer activity and their propency to intercalate into double stranded DNA.

CiteXplore: 19101158

DOI: 10.1016/j.bmc.2008.11.072

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