Document Report Card

ID: ALA1140928

Journal: J Med Chem

Title: Glycolipids and benzylammonium lipids as novel antisepsis agents: synthesis and biological characterization.

Authors: Piazza M, Rossini C, Della Fiorentina S, Pozzi C, Comelli F, Bettoni I, Fusi P, Costa B, Peri F.

Abstract: New glycolipids and a benzylammonium lipid were rationally designed by varying the chemical structure of a D-glucose-derived hit compound active as lipid A antagonist. We report the synthesis of these compounds, their in vitro activity as lipid A antagonists on HEK cells, and the capacity to inhibit LPS-induced septic shock in vivo. The lack of toxicity and the good in vivo activity suggest the use of some compounds of the panel as hits for antisepsis drug development.

CiteXplore: 19161283

DOI: 10.1021/jm801333m