Document Report Card
Basic Information
ID: ALA1141013
Journal: Bioorg Med Chem Lett
Title: Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: design, synthesis, and BK channel-opening activity.
Authors: Cui YM, Yasutomi E, Otani Y, Yoshinaga T, Ido K, Sawada K, Kawahata M, Yamaguchi K, Ohwada T.
Abstract: Oxime ether derivatives of the benzylic ketone of 12,14-dichlorodehydroabietic acid (diCl-DHAA, 4b) were synthesised, and their BK channel-opening activity was evaluated in an assay system of CHO-K1 cells expressing hBKalpha channels. Oxime ether structure on the B ring of diCl-DHAA significantly increased the BK channel-opening activity.
CiteXplore: 18990575