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ID: ALA1141063
Journal: Bioorg Med Chem Lett
Title: Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities.
Authors: Hosoda S, Tanatani A, Wakabayashi K, Nakano Y, Miyachi H, Nagasawa K, Hashimoto Y.
Abstract: Ligands possessing dual vitamin D3-agonistic (estimated as HL-60 monocytic cell differentiation induction) and androgen-antagonistic (estimated as testosterone-induced SC-3 cell growth inhibition) activities with various activity spectra were prepared based on a substituted bis-phenylmethane skeleton. Some of them were revealed to be potent androgen antagonists with a nonsecosteroidal vitamin D3 skeleton.
CiteXplore: 16019211