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ID: ALA1141208
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390.
Authors: Barboni L, Ballini R, Giarlo G, Appendino G, Fontana G, Bombardelli E.
Abstract: Starting from 10-deacetylbaccatin III (7), the 2-debenzoyl-2-m-methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized. The biological evaluation of these compounds (5 and 6, respectively) showed a general increase of cytotoxicity, as observed in first-generation anticancer taxanes.
CiteXplore: 16183281