Document Report Card
Basic Information
ID: ALA1141232
Journal: Bioorg Med Chem Lett
Title: Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1.
Authors: Zhang X, Urbanski M, Patel M, Zeck RE, Cox GG, Bian H, Conway BR, Pat Beavers M, Rybczynski PJ, Demarest KT.
Abstract: A series of benzo-fused heteroaryl-O-glucosides was synthesized and evaluated in SGLT1 and 2 cell-based functional assays. Indole-O-glucoside 10a and benzimidazole-O-glucoside 18 exhibited potent in vitro SGLT2 inhibitory activity.
CiteXplore: 16198559