Document Report Card

ID: ALA1141303

Journal: J Nat Prod

Title: Macrolactins O-R, glycosylated 24-membered lactones from Bacillus sp. AH159-1.

Authors: Zheng CJ, Lee S, Lee CH, Kim WG.

Abstract: In the course of screening for inhibitors of Staphylococcus aureus peptide deformylase, four new glycosylated macrolactin compounds, macrolactins O ( 1), P ( 2), Q ( 3), and R ( 4), along with the known macrolactins B ( 5) and C ( 6), have been isolated from the liquid cultures of Bacillus sp. AH159-1. The structures of compounds 1- 4 were assigned on the basis of MS and NMR data. They inhibited S. aureus peptide deformylase and also showed antibacterial activity against Escherichia coli and Staphylococcus aureus.

CiteXplore: 17887720

DOI: 10.1021/np0701327