Document Report Card

ID: ALA1141388

Journal: J Med Chem

Title: 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K.

Authors: Altmann E, Aichholz R, Betschart C, Buhl T, Green J, Irie O, Teno N, Lattmann R, Tintelnot-Blomley M, Missbach M.

Abstract: Starting from the purine lead structure 1, a new series of cathepsin K inhibitors based on a pyrimidine scaffold have been explored. Investigations of P3 and P2 substituents based on molecular modeling suggestions resulted in potent cathepsin K inhibitors with an improved selectivity profile over other cathepsins.

CiteXplore: 17256925

DOI: 10.1021/jm0613525