Document Report Card

ID: ALA1141461

Journal: J Nat Prod

Title: Polyene antibiotics from Streptomyces mediocidicus.

Authors: Cai P, Kong F, Fink P, Ruppen ME, Williamson RT, Keiko T.

Abstract: Three polyene antibiotics, mediomycins A (1), B (2), and clethramycin (3), were isolated from Streptomyces mediocidicus ATCC23936. Their structures were elucidated through extensive NMR study coupled with chemical reactions and MS/MS fragmentation analysis. All three compounds are linear polyenes consisting of a conjugated oxo-triene group and a hexaene moiety. Compounds 1 and 2 are new polyenes. All three compounds demonstrated a broad spectrum of antifungal activity in vitro.

CiteXplore: 17315962

DOI: 10.1021/np060542f