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ID: ALA1141500
Journal: Bioorg Med Chem Lett
Title: Thiol-based angiotensin-converting enzyme 2 inhibitors: P1' modifications for the exploration of the S1' subsite.
Authors: Deaton DN, Graham KP, Gross JW, Miller AB.
Abstract: Explorations of the S(1') subsite of ACE2 via modifications of the P(1') methylene biphenyl moiety of thiol-based metalloprotease inhibitors led to improvements in ACE2 selectivity versus ACE and NEP, while maintaining potent ACE2 inhibition.
CiteXplore: 18243695