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ID: ALA1141507
Journal: Bioorg Med Chem Lett
Title: Entry into a new class of protein kinase inhibitors by pseudo ring design.
Authors: Furet P, Caravatti G, Guagnano V, Lang M, Meyer T, Schoepfer J.
Abstract: A pyrimidin-4-yl-urea motif forming a pseudo ring by intramolecular hydrogen bonding has been designed to mimic the pyrido[2,3-d]pyrimidin-7-one core structure of a well-established class of protein kinase inhibitors. Potent inhibition of a number of protein kinases was obtained with the first prototype compound synthesized to probe the design concept.
CiteXplore: 18248988