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ID: ALA1141545
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors.
Authors: Lee J, Choi H, Kim KH, Jeong S, Park JW, Baek CS, Lee SH.
Abstract: A novel series of 3,5-diaminoindazoles were prepared and found to be CDK inhibitors. Potent inhibitors against CDK1 and CDK2 were obtained by introduction of 1lambda(6)-isothiazolidine-1,1-dioxide at 5-position of indazole. Anti-proliferative activities of compounds were evaluated using EJ, HCT116, SW620, and A549 cancer cell lines.
CiteXplore: 18353638