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ID: ALA1141715
Journal: Bioorg Med Chem Lett
Title: Novel BK channel openers containing dehydroabietic acid skeleton: structure-activity relationship for peripheral substituents on ring C.
Authors: Cui YM, Yasutomi E, Otani Y, Yoshinaga T, Ido K, Sawada K, Ohwada T.
Abstract: A series of dehydroabietic acid (DHAA, 2) derivatives was synthesized and evaluated as BK channel openers in an assay system of CHO-K1 cells expressing hBKalpha channels. Systematic modifications of the peripheral functionality of ring C of DHAA showed that the introduction of a nitro or (thio)urea group in ring C greatly enhanced the BK channel-opening activity.
CiteXplore: 18789860