Document Report Card

ID: ALA1141853

Journal: J Nat Prod

Title: A cyclitol derivative as a replication inhibitor from the marine sponge Petrosia sp.

Authors: Kim DK, Lim YJ, Kim JS, Park JH, Kim ND, Im KS, Hong J, Jung JH.

Abstract: A bioactive cyclitol derivative (1) was isolated from the marine sponge Petrosia sp. The chemical structure of 1 was determined as (2S)-1-O-(2',3',4',5'-tetrahydroxycyclopentyl)-3-O-(10' '-methylhexadecyl)glycerol. Compound 1 inhibited DNA replication in vitro at the level of initiation.

CiteXplore: 10346968

DOI: 10.1021/np9804785