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ID: ALA1141860
Journal: Bioorg Med Chem Lett
Title: Synthesis and monoamine transporter affinity of 3-aryl substituted trop-2-enes.
Authors: Krunic A, Mariappan SV, Reith ME, Dunn WJ.
Abstract: A series of new 3-aryl-tropanes have been synthesized, and their affinities and selectivities were evaluated for monoamine transporters. (1RS)-3-(Fluoren-2-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene exhibited the highest affinity for the human serotonin transporter (IC(50)=14.5nM). It is also 52-fold and 230-fold selective over human dopamine and norepinephrine transporters, respectively.
CiteXplore: 16202585