Document Report Card

ID: ALA1141877

Journal: J Med Chem

Title: Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors.

Authors: Feng S, Wang Z, He X, Zheng S, Xia Y, Jiang H, Tang X, Bai D.

Abstract: By targeting dual active sites of AChE, a series of bis-huperzine B analogues with various lengths of the tether were designed, synthesized, and tested for their inhibition and selectivity. The most potent bis-huperzine B (5g) exhibited 3900-fold increase in AChE inhibition and 930-fold greater in selectivity for AChE vs BuChE than its parent huperzine B.

CiteXplore: 15689148

DOI: 10.1021/jm0496178