Document Report Card
Basic Information
ID: ALA1141904
Journal: Bioorg Med Chem Lett
Title: Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor alpha and their bioactivities in vivo.
Authors: Yang C, Xu G, Li J, Wu X, Liu B, Yan X, Wang M, Xie Y.
Abstract: The synthesis of benzothiophenes containing a piperazine side chain and their binding affinities for estrogen receptors are described. These compounds bearing piperazine side chains were identified to be high-affinity ligands with high selectivity for ER alpha subtype. They were also potent agonists in bone tissue.
CiteXplore: 15713417