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ID: ALA1141910
Journal: Bioorg Med Chem Lett
Title: Combinatorial approaches towards the discovery of new tryptase inhibitors.
Authors: del Fresno M, Fernández-Forner D, Miralpeix M, Segarra V, Ryder H, Royo M, Albericio F.
Abstract: The synthesis and evaluation as tryptase inhibitors of a library of 2,5-diketopiperazine derivatives containing guanidine or amidine functional groups is reported. Among the compounds evaluated, derivatives 6{CG4-CG8} and 6{CG4-CG9} are the most active compounds and have marked selectivity towards tryptase in front of trypsin.
CiteXplore: 15745817