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ID: ALA1141941

Journal: Bioorg Med Chem Lett

Title: Biaryl diamides as potent melanin concentrating hormone receptor 1 antagonists.

Authors: Palani A, Shapiro S, McBriar MD, Clader JW, Greenlee WJ, O'Neill K, Hawes B.

Abstract: Herein, we report the discovery of the potent and selective biaryl diamide derived MCH-R1 receptor antagonist 1, which was identified upon modification of a previously disclosed biaryl urea series. This paper describes one of the strategies incorporated to remove the highly mutagenic biarylaniline present in an otherwise promising biaryl urea series.

CiteXplore: 16202583

DOI: 10.1016/j.bmcl.2005.08.043