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ID: ALA1141941
Journal: Bioorg Med Chem Lett
Title: Biaryl diamides as potent melanin concentrating hormone receptor 1 antagonists.
Authors: Palani A, Shapiro S, McBriar MD, Clader JW, Greenlee WJ, O'Neill K, Hawes B.
Abstract: Herein, we report the discovery of the potent and selective biaryl diamide derived MCH-R1 receptor antagonist 1, which was identified upon modification of a previously disclosed biaryl urea series. This paper describes one of the strategies incorporated to remove the highly mutagenic biarylaniline present in an otherwise promising biaryl urea series.
CiteXplore: 16202583