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ID: ALA1141942
Journal: Bioorg Med Chem Lett
Title: Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors.
Authors: Birch HL, Buckley GM, Davies N, Dyke HJ, Frost EJ, Gilbert PJ, Hannah DR, Haughan AF, Madigan MJ, Morgan T, Pitt WR, Ratcliffe AJ, Ray NC, Richard MD, Sharpe A, Taylor AJ, Whitworth JM, Williams SC.
Abstract: The synthesis and biological activity of a novel series of 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones are described. Some of these compounds were found to be potent inhibitors of inosine 5'-monophosphate dehydrogenase type II (IMPDH II).
CiteXplore: 16202581