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ID: ALA1141948
Journal: Bioorg Med Chem Lett
Title: Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors.
Authors: Zbinden KG, Obst-Sander U, Hilpert K, Kühne H, Banner DW, Böhm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lavé T.
Abstract: We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.
CiteXplore: 16213138