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ID: ALA1141967
Journal: Bioorg Med Chem Lett
Title: N-Sulfonyl hydroxamate derivatives as inhibitors of class II fructose-1,6-diphosphate aldolase.
Authors: Gavalda S, Braga R, Dax C, Vigroux A, Blonski C.
Abstract: Dihydroxyacetone-phosphate and phosphonate derivatives were synthesized bearing a N-sulfonyl hydroxamate moiety. The phosphate derivatives represent competitive inhibitors for the class II-FBP aldolase catalyzed reaction, while the phosphonate isosteres are comparatively weaker inhibitors.
CiteXplore: 16236509