Document Report Card
Basic Information
ID: ALA1141988
Journal: Bioorg Med Chem Lett
Title: Bis(aminopyrrolidine)-derived ureas (APUs) as potent MCH1 receptor antagonists.
Authors: Grey J, Dyck B, Rowbottom MW, Tamiya J, Vickers TD, Zhang M, Zhao L, Heise CE, Schwarz D, Saunders J, Goodfellow VS.
Abstract: Ureas derived from two substituted 3-aminopyrrolidine subunits were prepared as constrained analogs of a linear lead compound and tested as antagonists of the MCH(1) receptor. The series was optimized for substitution and stereochemistry to generate a functional antagonist with a K(i) of 3.3 nM and IC(50) of 12 nM (GTPgammaS).
CiteXplore: 15686900