Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors.

ID: ALA1142016

Journal: Bioorg Med Chem Lett

Title: Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors.

Authors: Vlahakis JZ, Kinobe RT, Bowers RJ, Brien JF, Nakatsu K, Szarek WA.

Abstract: Several analogues based on the lead structure of azalanstat were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). A number of these compounds, which are structurally distinct from metalloporphyrin HO inhibitors, were found to be selective for the HO-1 isozyme (stress induced), and had substantially less inhibitory activity on HO-2, the constitutive isozyme.

CiteXplore: 15713406

DOI: 10.1016/j.bmcl.2004.12.075

Patent ID: ┄