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ID: ALA1142024
Journal: Bioorg Med Chem Lett
Title: Glucokinase-activating ureas.
Authors: Castelhano AL, Dong H, Fyfe MC, Gardner LS, Kamikozawa Y, Kurabayashi S, Nawano M, Ohashi R, Procter MJ, Qiu L, Rasamison CM, Schofield KL, Shah VK, Ueta K, Williams GM, Witter D, Yasuda K.
Abstract: The synthesis, SAR and biological evaluation of a series of ureas that activate glucokinase, a target for diabetes therapy as a result of its critical role in the regulation of whole-body glucose homeostasis, are described. Some of the urea-containing glucokinase activators lowered blood glucose levels in vivo following oral dosing to C57BL/6J mice.
CiteXplore: 15713416