Your company account is blocked and you cannot place orders. If you have questions, please contact your company administrator.

Document Report Card

Basic Information

ID: ALA1142024

Journal: Bioorg Med Chem Lett

Title: Glucokinase-activating ureas.

Authors: Castelhano AL, Dong H, Fyfe MC, Gardner LS, Kamikozawa Y, Kurabayashi S, Nawano M, Ohashi R, Procter MJ, Qiu L, Rasamison CM, Schofield KL, Shah VK, Ueta K, Williams GM, Witter D, Yasuda K.

Abstract: The synthesis, SAR and biological evaluation of a series of ureas that activate glucokinase, a target for diabetes therapy as a result of its critical role in the regulation of whole-body glucose homeostasis, are described. Some of the urea-containing glucokinase activators lowered blood glucose levels in vivo following oral dosing to C57BL/6J mice.

CiteXplore: 15713416

DOI: 10.1016/j.bmcl.2004.12.083