Document Report Card

ID: ALA1142105

Journal: J Nat Prod

Title: Bioactive metabolites from the Caribbean sponge Aka coralliphagum.

Authors: Grube A, Assmann M, Lichte E, Sasse F, Pawlik JR, Köck M.

Abstract: The chemistry of the burrowing sponge Aka coralliphagum was investigated to identify chemically labile secondary metabolites. The HPLC-MS analysis of the two growth forms typica and incrustans revealed different metabolites. The previously unknown sulfated compounds siphonodictyals B1 to B3 (6-8), corallidictyals C (9) and D (10), and siphonodictyal G (11) were isolated, and their structures were elucidated by NMR and MS experiments. The compounds were tested in a DPPH assay, in antimicrobial assays against bacteria, yeasts, and fungi, and in antiproliferation assays using cultures of mouse fibroblasts. The biological activity was linked to the presence of the ortho-hydroquinone moiety.

CiteXplore: 17309298

DOI: 10.1021/np0603018