Document Report Card

ID: ALA1142113

Journal: J Nat Prod

Title: Limonoids from the seeds of the marine mangrove Xylocarpus granatum.

Authors: Yin S, Wang XN, Fan CQ, Lin LP, Ding J, Yue JM.

Abstract: Five new limonoids, granaxylocarpins A-E (1-5), were isolated from the seeds of the Chinese marine mangrove Xylocarpus granatum. Granaxylocarpins A (1) and B (2) are mexicanolide-type limonoids with a 9,10-seco skeleton, and granaxylocarpin C (3) possesses an 8alpha,30alpha-epoxy ring and a rare 1,29-oxygen bridge. The structures of these limonoids were characterized on the basis of extensive spectroscopic methods and single-crystal X-ray diffraction analysis performed on 4. The structure of xyloccensin U (4a) was revised as 4b by comparison with granaxylocarpin D (4). The cytotoxicity of these isolates was evaluated against the P-388 and A-549 tumor cell lines.

CiteXplore: 17323995

DOI: 10.1021/np060632k