Document Report Card

ID: ALA1142123

Journal: J Nat Prod

Title: Guttiferones K and L, antiproliferative compounds of Rheedia calcicola from the Madagascar rain forest.

Authors: Cao S, Brodie PJ, Miller JS, Ratovoson F, Birkinshaw C, Randrianasolo S, Rakotobe E, Rasamison VE, Kingston DG.

Abstract: Bioassay-guided fractionation of the ethanol extract obtained from the fruits of Rheedia calcicola led to the isolation of two new guttiferone analogues, guttiferones K (1) and L (16-hydroxyguttiferone K) (2). The structures of 1 and 2 were established on the basis of extensive interpretation of one- and two-dimensional NMR spectroscopic data. Both compounds were tested for their antiproliferative activity against the A2780 human ovarian cancer cell line.

CiteXplore: 17348706

DOI: 10.1021/np070004i