Document Report Card

ID: ALA1142129

Journal: Antimicrob Agents Chemother

Title: Effect of carbapenem administration on establishment of intestinal colonization by vancomycin-resistant enterococci and Klebsiella pneumoniae in mice.

Authors: Stiefel U, Pultz NJ, Donskey CJ.

Abstract: In a mouse model, ertapenem inhibited the anaerobic intestinal microflora and promoted overgrowth of enterococci, whereas imipenem-cilastatin had no effect on the indigenous microflora. Ertapenem, but not imipenem-cilastatin, promoted modest overgrowth of vancomycin-resistant enterococci when exposure occurred during treatment. Neither agent promoted colonization with extended-spectrum beta-lactamase-producing Klebsiella pneumoniae.

CiteXplore: 17043115

DOI: 10.1128/aac.00355-06