Document Report Card

ID: ALA1142161

Journal: Antimicrob Agents Chemother

Title: Hepatitis C virus (HCV) NS5B nonnucleoside inhibitors specifically block single-stranded viral RNA synthesis catalyzed by HCV replication complexes in vitro.

Authors: Yang W, Sun Y, Phadke A, Deshpande M, Huang M.

Abstract: Replication complexes of hepatitis C virus synthesized two major species of viral RNA in vitro, double stranded and single stranded. NS5B nonnucleoside inhibitors inhibited dose dependently the synthesis of single-stranded RNA but not double-stranded RNA. Moreover, replication complexes carrying a mutation resistant to a nonnucleoside inhibitor lost their susceptibilities to the inhibitor.

CiteXplore: 17088480

DOI: 10.1128/aac.00498-06