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ID: ALA1142254
Journal: Bioorg Med Chem Lett
Title: 5'-Fluoro-5'-deoxyaristeromycin.
Authors: Li W, Yin X, Schneller SW.
Abstract: 5'-Fluoro-5'-deoxyaristeromycin (2) has been prepared via a Mitsunobu coupling of (1S,2S,3R,4S)-2,3-(cyclopentylidenedioxy)-4-fluoromethylcyclopentan-1-ol with N6-bis-boc protected adenine. This procedure is adaptable to preparing a number of 5'-fluoro-5'-deoxycarbocyclic nucleoside analogs with diversity in the heterocyclic base. Antiviral analysis found promising activity for 2 toward measles but no other viruses. No cytotoxicity was observed for 2.
CiteXplore: 18023578