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ID: ALA1142255
Journal: Bioorg Med Chem Lett
Title: Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.
Authors: Iserloh U, Wu Y, Cumming JN, Pan J, Wang LY, Stamford AW, Kennedy ME, Kuvelkar R, Chen X, Parker EM, Strickland C, Voigt J.
Abstract: Based on lead compound 1 identified from the patent literature, we developed novel patentable BACE-1 inhibitors by introducing a cyclic amine scaffold. Extensive SAR studies on both pyrrolidines and piperidines ultimately led to inhibitor 2f, one of the most potent inhibitors synthesized to date.
CiteXplore: 18023580