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ID: ALA1142293
Journal: Bioorg Med Chem Lett
Title: Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite.
Authors: Deaton DN, Gao EN, Graham KP, Gross JW, Miller AB, Strelow JM.
Abstract: Screening of a metalloprotease library led to the identification of a thiol-based dual ACE/NEP inhibitor as a potent ACE2 inhibitor. Modifications of the P(1) benzyl moiety led to improvements in ACE2 potency as well as to increased selectivity versus ACE and NEP.
CiteXplore: 18078750