Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as alpha-glucosidase inhibitors.
Basic Information
ID: ALA1142322
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as alpha-glucosidase inhibitors.
Authors: Hari Babu T, Rama Subba Rao V, Tiwari AK, Suresh Babu K, Srinivas PV, Ali AZ, Madhusudana Rao J.
Abstract: A series of 8-aminomethylated derivatives (1a-1j) were prepared by Mannich reaction of oroxylin A (1) with appropriate primary or secondary amines and para-formaldehyde. All the compounds were tested for their alpha-glucosidase inhibition activity against both yeast and rat intestinal alpha-glucosidase. Some of the compounds demonstrated significantly better alpha-glucosidase inhibitory activity than the parent compound (oroxylin A).
CiteXplore: 18255289
DOI: 10.1016/j.bmcl.2008.01.055
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