Document Report Card

Basic Information

ID: ALA1142417

Journal: Bioorg Med Chem

Title: Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones.

Authors: Valderrama JA, Leiva H, Rodríguez JA, Theoduloz C, Schmeda-Hirshmann G.

Abstract: A series of naphthoquinones 2,3-disubstituted with chlorine and oxyethylene groups have been prepared from 2,3-dichloro- and 2,3-dimethoxy-1,4-naphthoquinone. The members of these series were tested on normal human fibroblasts and on a panel of four human cancer cell lines. Antitumor activities, which were in the range of IC(50) 1.3-89.5 microM, discussed in terms of LUMO energy, lipophilicity and size of the polyoxyethylene moiety.

CiteXplore: 18299197

DOI: 10.1016/j.bmc.2008.02.018