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ID: ALA1142463
Journal: Bioorg Med Chem Lett
Title: Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA.
Authors: Oslund RC, Cermak N, Verlinde CL, Gelb MH.
Abstract: Simplified analogs of YM-26734, a known inhibitor of secreted phospholipase A(2) (sPLA(2)) group IIA, were synthesized and found to also display potent inhibition at low nanomolar concentrations. Analogs were based on the didodecanoylphloroglucinol portion of YM-26734 which contains the predicted active site calcium binding group.
CiteXplore: 18818074