Basic Information
ID: ALA1142467
Journal: Bioorg Med Chem Lett
Title: A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity.
Authors: Magrioti V, Naxakis G, Hadjipavlou-Litina D, Makriyannis A, Kokotos G.
Abstract: A variety of long chain 1,2-diamines and related compounds were synthesized and tested for their activity on fatty acid amide hydrolase (FAAH) and monoacyglycerol lipase (MGL). (2S,9Z)-Octadec-9-ene-1,2-diamine selectively inhibits MGL (K(i) 21.8 microM) without significantly affecting FAAH. This compound exhibited interesting in vivo analgesic and anti-inflammatory properties, suggesting that selective inhibitors of MGL may be valuable novel agents for the treatment of inflammatory pain.
CiteXplore: 18819796
DOI: 10.1016/j.bmcl.2008.09.039
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets