Document Report Card

ID: ALA1142558

Journal: J Nat Prod

Title: A new polyether ladder compound produced by the dinoflagellate Karenia brevis.

Authors: Bourdelais AJ, Jacocks HM, Wright JL, Bigwarfe PM, Baden DG.

Abstract: A new ladder-frame polyether compound containing five fused ether rings was isolated from laboratory cultures of the marine dinoflagellate Karenia brevis. This compound, named brevenal, and its dimethyl acetal derivative both competitively displace brevetoxin from its binding site in rat brain synaptosomes. Significantly, these compounds are also nontoxic to fish and antagonize the toxic effects of brevetoxins in fish. The structure and biological activity of brevenal, as well as the dimethyl acetal derivative, are described in this paper.

CiteXplore: 15679307

DOI: 10.1021/np049797o