Synthesis, antitumor evaluation, and apoptosis-inducing activity of hydroxylated (E)-stilbenes.

Basic Information

ID: ALA1142677

Journal: J Med Chem

Title: Synthesis, antitumor evaluation, and apoptosis-inducing activity of hydroxylated (E)-stilbenes.

Authors: Lion CJ, Matthews CS, Stevens MF, Westwell AD.

Abstract: The parallel solution-phase synthesis of a series of 30 monohydroxylated (E)-stilbene analogues is described. In vitro screening revealed low micromolar activity (GI(50)) against the MDA MB 468 breast cancer cell line. Activity in MDA MB 468 cells correlated with the ability to induce apoptosis following drug treatment by the most potent agents in the series, e.g., 5dy and 5jy, an observation further reinforced by AnnexinV-FITC analysis and fluorescence microscopy.

CiteXplore: 15715501

DOI: 10.1021/jm049238e

Patent ID: ┄