New alpha-methylene-gamma-butyrolactones with antimycobacterial properties.
Basic Information
ID: ALA1142794
Journal: Bioorg Med Chem Lett
Title: New alpha-methylene-gamma-butyrolactones with antimycobacterial properties.
Authors: Hughes MA, McFadden JM, Townsend CA.
Abstract: The synthesis and antimycobacterial activity of a series of alpha-methylene-gamma-butyrolactones based on the natural product protolichesterinic acid are described. Compounds 9-12 bearing an allylamide group at the C-4 position showed improved activity with MICs in the range of 6.25-12.5 microg/mL.
CiteXplore: 16002282
DOI: 10.1016/j.bmcl.2005.05.119
Patent ID: ┄
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