Comparison of different heterocyclic scaffolds as substrate analog PDE5 inhibitors.

ID: ALA1142799

Journal: Bioorg Med Chem Lett

Title: Comparison of different heterocyclic scaffolds as substrate analog PDE5 inhibitors.

Authors: Haning H, Niewöhner U, Schenke T, Lampe T, Hillisch A, Bischoff E.

Abstract: Several different heterocyclic systems were compared as PDE5 inhibitor scaffolds. In addition to the known 3H-imidazo[5,1-f][1,2,4]triazin-4-ones and pyrazolopyrimidinones, isomeric imidazo[1,5-a][1,3,5]triazin-4(3H)-ones were also shown to be potent and selective PDE inhibitor scaffolds with in vivo activity. SAR trends were elucidated for sulfonamide derivatives with generality across different scaffolds.

CiteXplore: 15993055

DOI: 10.1016/j.bmcl.2005.05.090

Patent ID: ┄